Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
4. New reserves of helium discovered
But most overseas islands are sold as freehold properties.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
The Bloomberg soft commodities index has gained 21 per cent, compared with 24 per cent for industrial metals and 1.5 per cent for energy.
Trends and targets in antiviral phototherapy
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Among the 18 sectors categorized by the China Securities Regulatory Commission, financial executives ranked the highest with annual pay of 27.36 million yuan, followed by real estate executives at 11.18 million yuan.
Others have come up with some, um, creative ways to say sayonara. When staffing firm OfficeTeam asked about 600 U.S. human resources managers to describe the weirdest ways they’ve seen or heard people resign lately, here’s what they said:
ACE2 as a potential therapeutic target for pandemic COVID-19
法国电信商学院(Télécom Business School)和布拉格经济大学(University of Economics)的教师性别比例最为均衡，女教师占50%，瑞士苏黎世大学(University of Zurich)的教师性别比例最不均衡，女教师仅为9%。瑞士洛桑国际管理发展学院(IMD)的教师队伍国际化程度最高，94%来自海外，米兰理工大学MIP管理学院的教师则均为意大利人。
Diagnostic technologies for COVID-19: a review
18. Most Interesting Apology (tie) On Nov. 18, The Hollywood Reporter disgorged a 1,200-plus word apology for not including any nonwhite performer in its Oscar actress round table. Soon after, the director Alex Proyas and Lionsgate apologized for the lack of diversity in the cast in their new movie “Gods of Egypt.”
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
9.Fantastic Beasts and Where to Find Them
And while there is still a long way to go before airplanes designed and made in China compete on the world stage with the likes of the Boeing 737 or Airbus A320, the momentum is there, and the country’s aerospace industry is entering a new phase of development and maturity.
9) Well Done: It’s a cliché, no doubt. Sometimes, it isn’t enough just to say thanks. People want to know what they did was great and why. They pour so much sweat and soul into their projects.They need to know their work was special and had meaning to someone.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Despite car and truck sales that motored past 16 million for the first time since 2007, recalls dominated the news for most of the year. General Motors GM 1.42% held center stage, dealing with cascading revelations about faulty ignition switches and recalling millions of vehicles. While GM opted for something approaching full disclosure of its missteps , publishing an report into company-wide fumbles, Japanese airbag maker Tanaka chose to stonewall. It left any remedies up to its beleaguered customers, notably Honda and Toyota. They are the ones who deal with the fallout of exploding safety devices that fatally fired shrapnel throughout the passenger compartment.
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Common areas include two living rooms, both with walls of glass opening to a patio and an in-ground pool. Ceilings rise as high as 28 feet; doors throughout are Spanish cedar. Among the stainless-steel kitchen appliances are a Fisher & Paykel range and two Sub-Zero refrigerators, as well as steel cabinets and sinks. A breakfast bar separates the kitchen from the dining area, which also opens to the patio and pool.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
After her legal travails , anything Kesha released would have a veneer of triumph. But this comeback set was an artistic warrior cry more potent than any might've expected.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
1. You became a LinkedIn superstar overnight。
Antiviral drug discovery: broad-spectrum drugs from nature
*Directing for a Variety Series: Ryan McFaul, “Inside Amy Schumer”
Today, the Financial Times reveals the fake gross domestic product data routinely released from many northern Chinese regions. There, solid alternative evidence suggests the authorities have “smoothed” the economic growth figures. They artificially boosted growth figures between 2012 and 2016, masking a real downturn, and last year covered up a genuine recovery.
The nearest star, Proxima Centauri, has a planet orbiting it not much bigger than Earth. Its "year" is only 11 days. But it's in the habitable zone because Proxima Centauri is a red dwarf star about 100 times fainter than the sun. And there's hot news that a similar star, 40 light years away, may have three planets in its habitable zone.
Influenza neuraminidase: A druggable target for natural products
The joint programme delivered by Tsinghua and Insead University (Tiemba) moved up two places to lead the 2015 global executive MBA ranking, dethroning Trium, which drops back to third place after only one year at the top.
As it happened, the lenders to Seppenwolde never lost a guilder. Within weeks, they had liquidated all the East India shares and had recovered the money they had loaned.
Jonathan Glazer’s Under the Skin is a film about a beautiful, scary alien that is itself beautiful and scary and alien: it’s an entirely extraordinary, outrageously sensual film that Glazer’s previous excellent work had really only hinted at, partially and indistinctly. His Sexy Beast (2000) was a visually accomplished, exciting and intelligent crime thriller that was way ahead of the woeful mockney-geezer mode of the time. Birth (2004) had Kubrickian ingenuity and chill, with some remarkable moments; it was a movie that deserves cult-classic status but has yet to achieve it. Then a decade went by, and it seemed that Glazer might be a stylist for whom a sustained cinema career would perhaps not be achievable (and heaven knows, it can happen to the most talented).
“Policymakers around the world are cognisant of the impact the Fed decision will have and are worried, which makes us worried,” said Simon Lue-Fong, head of global emerging debt at Pictet Asset Management. “People are saying the decision is priced in but seeing as no one knows exactly what will happen how can that possibly be true.”
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
6. 《火星救援》(The Martian)。在布满红色岩石的山坡与丘陵之间，雷利·斯科特(Ridley Scott)这部非常令人满意的太空西部片既源自一个历史悠久的类型，也源自他的殿堂级遗产。
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The pickup in consumption in turn will entice businesses to hire and invest more to keep up with rising sales. The result: The U.S. is likely to grow more than 3% for the first time since 2005.
Back in the movie wasteland of last January, no one could have guessed what a bounty of good films the year would bring. Not just good films, but several that measure up to our idealized notions of what the medium once was. Two candidates for the top of the heap pretty much chose themselves. For sheer entertainment, the clear call is 'American Hustle,' David O. Russell's joyous celebration of 1970s-era con artists and their intricate cons. For innovation-a new theatrical experience born of new technology-'Gravity' whirls in its own orbit. With the understanding that there's nothing to be said against 'American Hustle,' and everything to recommend this screwball comedy for the ages, I think 'Gravity' is the best movie of the year.
而其他的队伍还有在尝试赢球的。小牛队，在3-13的战绩面前，骄傲地说他们不会垫底。但是，明年被认为是近年来最好的NBA选秀，有Markelle Fultz, Jayson Tatum, Lonzo Ball, Josh Jackson, Harry Gile, OG Anumoby, Ivan Rabb……等等优质球员。
《癌症：众病之王》(Cancer: The Emperor of All Maladies)，PBS，3月30日播出。该剧由《斯科茨伯勒：美国的悲剧》(Scottsboro: An American Tragedy)与《美莱》(My Lai)的导演巴拉克·古德曼(Barak Goodman)执导，肯·伯恩斯(Ken Burns)担任执行制作人，这部六小时的剧集是根据普利策获奖书籍、悉达多·穆克吉(Siddhartha Mukherjee)医生的《众病之王：癌症传》(The Emperor of All Maladies: A Biography of Cancer)改编的。
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Good luck, good health, hood cheer. I wish you a happy New Year.
"As a native of Shaanxi, I found Sun played the role well. She jumps and runs wildly, just like a typical young naughty Shaanxi girl," a netizen Xuelili said.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
"It sounds like Harvard is intruding too deeply into the private lives of students," said Dershowitz, who has represented a series of high-profile clients, including OJ Simpson.
China becomes the first middle-income country to join the ranks of the world's 25 most-innovative economies, according to the Global Innovation Index (GII) released last Monday.
Inhibition of SARS coronavirus helicase by bismuth complexes
My heart is my New Year present to you.我的心就是我奉献给你的新年礼物。
Mr Ravenscroft ended up leaving teaching to found Enabling Enterprise, a body that seeks to bridge the gulf between schools and business by taking pupils out of the classroom and giving them practical projects and visits to businesses, including UBS, the bank, and Freshfields, the law firm.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
At New Year and always, may peace and love fill your heart, beauty fill your world, and contentment and joy fill your days.新年的祝福，平日的希冀，愿你心境祥和、充满爱意，愿你的世界全是美满，愿你一切称心如意，快乐无比。
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Snap, however, has sunk to about $15 after initially rallying from its IPO price of $17 in March, damping some expectation of further activity involving so-called decacorns, tech companies that have achieved valuations of $10bn or more through private funding.
“BlackBerry has not engaged in discussions with Samsung with respect to any possible offer to purchase BlackBerry,” the company said in a statement issued Wednesday afternoon. “BlackBerry’s policy is not to comment on rumors or speculation, and accordingly it does not intend to comment further.”
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Seoul insists the activists have a democratic right to send the leaflets, but has appealed for restraint to avoid overly provoking the North.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
More importantly, their inventions may even eventually be turned into products that benefit mankind.
The website claims that "the more you sip, the smarter you (and the bottle) get," but in reality the more you sip, the drunker you get and the less information you'll retain.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
One of the men even swoops in to give the girl a quick kiss on the cheek. He turns around in mock-embarrassment and gives his friend a hug, while the young woman speaks to her friend in French.
For: The Los Angeles Critics Association gave it their top prize.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Users say the voice messages are transferred quickly enough to have a conversation on the platform. But different from free voice applications such as Microsoft Corp.'s Skype, it also offers the flexibility of answering messages at a later time. 'I can decide when to reply, or not to,' said Beijing WeChat user Robin Wang.
Only Kobe Bryant had played in more games by age 32, and did so with fewer minutes, and that's just including regular-season games.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
More than 350,000 gamers from across Europe (and some from North America and Asia) have made the annual pilgrimage to the quaint German city of Cologne, which has a population of just over 1 million. Activision used the convention to debut its multiplayer gameplay for Sledgehammer Games’ Call of Duty: Advanced Warfare, allowing attendees hands-on access to the November 3 release.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
In the past five years, China's exports of goods grew at an annual average of 6.5 percent, with its share in the global market rising form 10.4 percent in 2010 to about 13.2 percent in 2015, faring much better than major global economies. Service trade grew over 13.6 percent each year, marking the world's second largest service trader.
The fundamentals of the Chinese economy remain sound, the capital adequacy ratio and provision coverage of commercial bans remain high, and we have many financial tools and instruments that can be used. We have the confidence, the ability, and the means to forestall systemic risks.
The report also showed regions with a better-developed economy produce more cyberstars, with Beijing, Shanghai, Guangdong, Jiangsu and Zhejiang leading the rankings.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Taiwan Semiconductor Manufacturing Company (TSMC).” Previous reports have pegged the screen size at just under the 5 inches of Samsung’s Galaxy 4.
That was true, too, of “Mad Men” on AMC. which in its seventh season has all but exhausted its characters and its 1960s setting, but is still keeping viewers guessing about the end, which won’t air until next year. “The Sopranos” ended ambiguously. “Breaking Bad,” put an end to Walter White. Now, the next television mystery looming ahead centers on Don Draper’s last moments, dead or alive.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Apple CEO Tim Cook
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Further, 32 out of the 50 new selected female billionaires started their businesses from scratch.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Frankly, this is unlikely to be ready in time for next year, but we'll include it just in case. The second film from Laszlo Nemes, who won the foreign language Oscar earlier this year for Son of Saul, is a coming-of-age drama set in Budapest just before the first world war.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Tech giant Tencent's founder Pony Ma topped the list, with a fortune of 279 billion yuan, followed by Alibaba's Jack Ma, and Evergrande Group's Xu Jiayin, with their personal worth reaching 260 billion yuan, and 229 billion yuan, respectively.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
10. “移动珠宝”(Run the Jewels)，《移动珠宝2》，Mass Appeal。说到迫切和讥讽，杀手麦克(Killer Mike)和EL-P都是地下说唱界不同圈子里的资深人士了，他们组成的“移动珠宝”在第二张专辑里找到了坚实的互相吸引。他们的说唱强大有力，关注点狂热喧闹，专辑抨击没有让任何人摆脱困境的权力结构。
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
To make a long story short, the Seppenwolde group went bankrupt shortly after Christmas of 1772. The disaster was a top story in Dutch newspapers. It ruined some of Amsterdam’s merchants and bankers. To prevent a general credit collapse, the city of Amsterdam stepped in temporarily as a lender of last resort. Sound familiar?
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
When the cup is lifted and removed from the dispenser, the magnet seals the bottom and the drink is ready to be enjoyed.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
'Inside Llewyn Davis' finds the Coen brothers, Joel and Ethan, in a hauntingly somber mood that somehow translates into memorable drama. I think my review should have made it clearer that this elegy for a casualty of pop culture is a special taste; some of it is fairly glum. So much of it, though, gets to something stirring by way of Oscar Isaac's phenomenal performance as a self-defeating folk singer fatefully dedicated to his art.
A facile assay for rapid detection of COVID-19 antibodies
马修?麦康纳(Matthew McConaughey)和贾里德?莱托(Jared Leto) 均凭在剧情片《达拉斯买家俱乐部》(Dallas Buyers Club)中的真实演绎荣获金球奖，该片讲述了一群德克萨斯人向艾滋病病毒发起勇敢抗争的故事。获九次金球奖提名的莱昂纳多?迪卡普里奥(Leonardo DiCaprio)因在《华尔街之狼》(The Wolf of Wall Street)的出色表现第二次摘得最佳男演员桂冠。他在发表获奖感言时感谢了影片导演马丁?斯科塞斯(Martin Scorsese)对他的指导（该片是两人第五次合作），并感谢他“允许自己跟着他拍下了这部电影”。
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
New Year time is here. I hope you have a wonderful New Year. May every day hold happy hours for you.新年来临，祝新年快乐，愿你时时刻刻幸福欢乐！
The identity of the people buried in the cemetery is a mystery. The cemetery had been robbed in the past and no writing was found that indicates the names of those buried or their positions in life.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
20. 对电影爱好者的最佳建议。8月学者韦勒·温斯顿·迪克森(Wheeler Winston Dixon)发出了警告：“如果你上亚马逊，看到什么精彩的黑白电影卖三美元，或者其他什么外国电影和鲜为人知的电影，赶快买下来，因为它就要绝版了，他们不会再出版它们了。”成千上万这种VHS格式的电影不会被做成DVD格式或蓝光格式，迪克森警告说。而下载的美丽新世界（又名电子销售）明年将是好年头。
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Nearly half of the Kings' roster should have been traded following the Cousins teardown move and yet none were. Nice. Bring on Buddy Mania. Plenty of good seats still available.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Originally intended for the opening credits of Tomorrow Never Dies, and then for some reason relegated to the closing credits, K.D. Lang's "Surrender" is silken and cool. The horn sections are sassy and powerful. It's one of the best James Bond theme songs, and it's not even officially a James Bond theme song. And it's a heck of a lot better than the official theme the movie finally got.
Length-scale dependence of protein hydration-shell density
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
One tomb, dubbed "M3," contained carvings of several mythicalcreatures, including four that represent different seasons and parts of the heavens: the White Tiger of the West, the Vermilion Bird of the South, the Black Turtle of the North and the Azure Dragon of the East.
About this collection